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This site is intended for U.S. Healthcare Professionals.
To report an adverse event or product quality complaint, call 1-877-TAKEDA-7 (1-877-825-3327)
Not actual patients.
Currently, more than 550 different genetic defects of PID have been identified, often presenting with hallmark recurrent and unusual infections.1,2
Also, some patients develop a higher susceptibility to noninfectious complications such as malignancies, autoimmune diseases and allergies.3
The actual prevalence remains unclear, but estimates range from 390,000 to 6 million people living with PID worldwide.4 In the U.S. alone, the prevalence is thought to be as high as 50.5 cases per 100,000 people.5 Although severe forms are more frequent in infancy and early childhood, the disease may not manifest until later in life in some cases.6
PIDs are broadly classified, but antibody deficiencies represent the most common form and are characterized by impaired antibody-producing components. In the U.S., antibody deficiencies account for more than half of all PID cases (63.4%).7 Due to their unique role in antibody production, defects in B cell development and function are the main cause of antibody deficiencies. However, defects in T cells and other immune cell types that contribute to B cell activity may also be present.8
PIDs are significantly underreported, and estimates suggest that 70-90% of patients are undiagnosed worldwide, largely because it is not top of mind.6 According to a U.S. survey, the average time from symptom onset to diagnosis of all types of PID was 25 years based on 977 respondents.9 Diagnosing an antibody production deficit relies on a thorough medical and family history, physical examination and should be supplemented with diagnostic screening tests (e.g. complete blood count with differential white blood cell count, serum antibody levels, vaccine response) to help identify specific PID types.1,6
The clinical presentation of PIDs is highly variable; however, recurrent sinopulmonary and gastrointestinal infections are particularly common.1,8,10,11 Therefore, the management approach is highly dependent on the type of defect and is largely focused on the prevention and treatment of infections, while more severe cases may require hematopoietic stem cell transplants.1,8 The mainstay treatment for primary B-cell immunodeficiencies, is replacement of serum IgG with either intravenous immunoglobulin (IVIG) or subcutaneous immunoglobulin (SCIG).1,7 If left untreated, PID can lead to hospitalizations, frequent days missed from work/school, prolonged antibiotic use, permanent organ damage or even death.10,12,13
Annual meeting with the goal of providing a stimulating forum with presentations and discussions on the latest advances in clinical immunology, including primary immunodeficiencies and immune dysregulatory diseases.
National conference of IgNS bringing together professionals and practitioners from all disciplines and clinical specialties to advance Ig therapy practice, while providing networking and comprehensive education opportunities.
Annual meeting dedicated to the advancement of neuromuscular, musculoskeletal, and electrodiagnostic medicine.
Global meeting featuring thought leaders from around the world focused on advancing patient care in allergy and immunology.
Annual meeting in neurology promoting high quality patient-centric care in a variety of topics and specialties through various learning formats.
Annual conference ideal for infusion professionals or those seeking opportunities in the industry to come together and explore the latest trends in offering home-based services.
Premier global educational event for allergists and immunologists, with thousands of attendees each year, discussing allergies, asthma, and immune deficiency disorders.
Annual scientific session uniting allergists, immunologists, nurses, and physician assistants aimed at maintaining the highest standard of practice in allergy care.
This international congress offers attendees an updated view on neuromuscular disorders and networking opportunities to increase their international experience and collaborations.
Global meeting featuring thought leaders from around the world focused on advancing patient care in allergy and immunology.
National conference of IgNS bringing together professionals and practitioners from all disciplines and clinical specialties to advance Ig therapy practice, while providing networking and comprehensive education opportunities.
Biennial meeting that covers the latest discoveries in basic and clinical science covering our expanding field, bringing together internationally renowned scientists and clinicians to present and discuss major developments in diagnosis, clinical management, genetics, and immunobiology of inborn errors of immunity.
Annual meeting dedicated to the advancement of neuromuscular, musculoskeletal, and electrodiagnostic medicine.
Annual event with more than 2,500 members and non-members of the AMCP to engage on the latest innovations and most intentional networking in managed care pharmacy.
Annual congress for members of the allergy and immunology community, with a focus on HAE and PID in 2024.
Annual meeting offering the most up-to-date education in pulmonary, sleep, and critical care medicine through simulation sessions and original research presentations with clinical relevance to practitioners.
Annual conference aiming to advance knowledge about the cause(s), pathogenesis, epidemiology, and clinical manifestations of muscle disease and related neuromuscular disorders and to develop and implement strategies to examine promising therapeutic interventions.
Semi-annual conference of key opinion leaders in the Allergy, Asthma, and Immunology space.
A national conference offering exclusive continuing education, legislative policy updates, hands-on workshops, lively exhibitors, and networking opportunities for the nurse practitioner community.
The largest peripheral nerve meeting globally, offering the latest international research across specialties in peripheral neuropathy.
The Association of Pulmonary Advanced Practice Providers (APAPP) is the first association to focus solely on advanced practice providers (APPs) working in the realm of pulmonary medicine. Join over 200 nurse practitioners and physician associates for in-depth reviews and discussions highlighting the latest developments and current concepts in pulmonary, critical care, and sleep medicine.
The flagship meeting of the EAACI and the world’s largest congress specializing in the field of allergy and clinical immunology.
Regional annual conference discussing the most current information from top experts in allergy, asthma, and immunology.
International conference showcasing the latest advances in pulmonary disease, critical illness, and sleep disorders for scientists and clinicians at all stages of their careers.
Leading global conference discussing how to establish, incentivize, and share value sustainable for health systems, patients, and technology developers.
Annual meeting with the goal of providing a stimulating forum with presentations and discussions on the latest advances in clinical immunology, including primary immunodeficiencies and immune dysregulatory diseases.
Medication Resources
[Immune Globulin Infusion 10% (Human) with Recombinant Human Hyaluronidase] Solution
[Immune Globulin Infusion (Human)]
[Immune Globulin Subcutaneous (Human)] 20%
Videos
Watch videos focused on Primary Immunodeficiency Disease [PID (IEI)].
Learn about the cause of Primary Immunodeficiency Disease (PID)/Inborn Errors of Immunity (IEI) in this animated video.
Additional Resources
Find materials to help foster a deeper understanding of Primary Immunodeficiency Disease [PID (IEI)].
An overview of the overall health disparities and their impact on PID (IEI) patients.
An overview of PID (IEI) diagnosis including testing, impact of delayed diagnosis, and co-ordinating care.
An overview of PID (IEI) epidemiology, pathophysiology, signs and symptoms, and burden of disease.