Inflammatory Bowel Disease

The incidence of inflammatory bowel disease (IBD) has increased in recent years.1

Approximately 1.6 million Americans have IBD,1,2 which is comprised of 2 major types: ulcerative colitis (UC), characterized by continuous, mucosal inflammation limited to the innermost lining of the colon and rectum, and Crohn’s disease (CD), defined by patchy, transmural inflammation which can affect any part of the gastrointestinal (GI) tract, from the mouth to the perianal area.1,3,4

Inflammatory bowel disease illustration

Epidemiology

Population-based studies in the U.S. suggest that the incidence of IBD is most common in patients aged 15 to 35 years.1 IBD can also present in childhood, including up to 20% of children who are diagnosed before the age of 10 years.5 It is more common in Whites (vs other racial groups) and in adults, UC is more common in males.1,6

Diagnosis

Symptoms of IBD depend on the disease location, and can range from mild to moderate to severe.2,4 Diarrhea and rectal bleeding are characteristic with UC. Patients can experience weight loss and fever (although it can be less common than with CD), and abdominal pain varies depending on the patient. For CD, weight loss, fever, and abdominal pain are more predominant, although these patients can also experience diarrhea and rectal bleeding.4

Irritable bowel syndrome (IBS), the most common GI condition diagnosed by gastroenterologists, may be mistaken for IBD since IBS symptoms may mimic those seen in a patient with mild IBD, but history and additional diagnostic tests can help rule it out of the differential diagnosis.7 Endoscopy combined with biopsies of the affected area(s) of the GI tract will also establish the diagnosis and differentiate between UC and CD.4,8

Pathophysiology

The etiology of IBD most likely involves a complex interaction between genetic and environmental factors, microbiome, and the immune system.3,4 T cells, which are activated by antigen-presenting cells in the peripheral lymphoid tissue, migrate to the site of inflammation and play a role in recruitment and activation of additional inflammatory cells in the GI tract.9,10

Navigating IBD

IBD is a chronic disease, with significant impact on a patient’s general health.3 While the Crohn’s Disease Activity Index (for CD) and Mayo Score (for UC) are the most frequently used instruments for scoring and monitoring disease activity in clinical trials, researchers are working to improve the measures of disease activity and severity through assessment of impact of disease on the patient, disease burden, and disease course, including structural damage with a goal of improving disease management for patients.11

Upcoming & Past Conferences in Gastroenterology

  • Upcoming

  • Past

European Society for Clinical Nutrition & Metabolism Congress (ESPEN), 2024

September 7 - 10, 2024 | Link to Event

Annual global congress dedicated to clinical nutrition and metabolism, including basic and clinical research, education, and organization of consensus statements about clinical care.

United European Gastroenterology Week (UEGW), 2024

October 12 - 15, 2024 | Link to Event

Global congress for researchers from around the world to present their findings on gastroenterology and digestive health.

American College of Clinical Pharmacy (ACCP), 2024

October 12 - 15, 2024 | Link to Event

Annual event dedicated to excellence in clinical pharmacy practice, research, and education.

Academy of Managed Care Pharmacy Nexus (AMCP Nexus), 2024

October 14 - 17, 2024 | Link to Event

Annual event with more than 2,500 members and non-members of the AMCP to engage on the latest innovations and most intentional networking in managed care pharmacy.

American College of Allergy, Asthma & Immunology (ACAAI), 2024

October 24 - 28, 2024 | Link to Event

Global meeting featuring thought leaders from around the world focused on advancing patient care in allergy and immunology.

American College of Gastroenterology (ACG), 2024

October 25 - 30, 2024 | Link to Event

Premier event for clinicians and the general public about digestive disorders and the latest trends in GI technology and therapeutics.

North American Society For Pediatric Gastroenterology, Hepatology & Nutrition (NASPGHAN), 2024

November 6 - 9, 2024 | Link to Event

Annual forum for participants to learn about the latest advances in pediatric gastroenterology, hepatology, and nutrition, and to discuss current topics in clinical applications.

Advances in Inflammatory Bowel Diseases (AIBD), 2024

December 9 - 11, 2024 | Link to Event

An all-encompassing event providing real-world clinical education, case studies and new evidence-based approaches in IBD management.

Digestive Disease Week (DDW), 2024

May 18 - 21, 2024

Global meeting for physicians, researchers, and industry in the fields of gastroenterology, hepatology, endoscopy, and gastrointestinal surgery.

Professional Society for Health Economics and Outcomes Research (ISPOR), 2024

May 5 - 8, 2024

Leading global conference discussing how to establish, incentivize, and share value sustainable for health systems, patients, and technology developers.

Academy of Managed Care Pharmacy (AMCP), 2024

April 15 - 18, 2024

Large assembly of pharmacy and healthcare professionals dedicated to the issues of managed care pharmacy, offering immersive education sessions and keynote presentations.

Campaign Urging Research for Eosinophilic Disease (CURED), 2024

April 4 - 7, 2024

International meeting concerning the field of Eosinophilic Gastrointestinal Disorders, including EoE and other eosinophilic diseases.

  • Improved Histopathologic Features in Patients with Eosinophilic Esophagitis: Data from a Phase 3, Randomized, Placebo-Controlled Trial of Budesonide Oral Suspension

American Society for Parenteral and Enteral Nutrition (ASPEN), 2024

March 2 - 5, 2024

Annual global conference for interdisciplinary, clinical nutrition leaders, providing the latest in clinical nutrition research, education, and products.

Annual Meeting American Academy of Allergy Asthma and Immunology (AAAAI), 2024

February 23 - 26, 2024

Premier global educational event for allergists and immunologists, with thousands of attendees each year, discussing allergies, asthma, and immune deficiency disorders.

European Crohn's and Colitis Organisation

February 21 - 24, 2024

Annual global congress structured around basic science, traditional medicine and clinical sessions given by some of the world's top GI specialists.

Crohn's & Colitis Congress (CCC), 2024

January 25 - 25, 2024

Annual conference for a multidisciplinary community of practitioners and researchers focusing on inflammatory bowel disease (IBD) by pairing best practices in clinical care with innovative research.

Advances in Inflammatory Bowel Diseases (AIBD), 2023

December 14 - 16, 2023

An all-encompassing event providing real-world clinical education, case studies and new evidence-based approaches in IBD management.

Entyvio® (vedolizumab)

  • Biologic Therapy Sequencing in Ulcerative Colitis: A Real-World Observational Study of Second-Line Therapy After Vedolizumab

American College of Gastroenterology (ACG), 2023

October 20 - 25, 2023

Premier event for clinicians and the general public about digestive disorders and the latest trends in GI technology and therapeutics.

Entyvio® (vedolizumab)

  • Response Trajectory by the Clinical Decision Support Tool Probability Groups in Vedolizumab-Treated Patients With Crohn’s Disease: A Pooled Analysis of GEMINI 2, VISIBLE 2, and VERSIFY
  • Number Needed to Treat to Maintain Clinical Remission with Advanced Therapies in Patients with Moderate to Severe Ulcerative Colitis
  • Vedolizumab Long-Term Treatment Persistence and Safety – Results From a Multinational Extended Access Program Study
  • Corticosteroid-Free Remission in Anti-TNF-Failed Crohn’s Disease Patients Treated With Vedolizumab as Second-Line Biologic Therapy: A Real-World Data Review
  • Real-World Clinical Effectiveness and Safety of Vedolizumab and Ustekinumab in Bio-Naïve Patients With Late Crohn’s Disease: Results From the EVOLVE Expansion Study
  • Healthcare Resource Utilization and Costs Across Different Sequences of Advanced Therapies in Patients with Crohn’s Disease or Ulcerative Colitis

Motegrity® (prucalopride)

  • Efficacy and safety of prucalopride in patients with chronic idiopathic constipation from different racial and ethnic groups: a post hoc analysis of phase 3 and 4 clinical study data

Academy of Managed Care Pharmacy Nexus (AMCP Nexus), 2023

October 16 - 19, 2023

Annual event with more than 2,500 members and non-members of the AMCP to engage on the latest innovations and most intentional networking in managed care pharmacy.

  • Costs and Patient Characteristics Associated With High Versus Low Healthcare Resource Utilization in Patients With Inflammatory Bowel Disease: a Real-World Study in the USA

United European Gastroenterology Week (UEGW), 2023

October 14 - 17, 2023

Global congress for researchers from around the world to present their findings on gastroenterology and digestive health.

Entyvio® (vedolizumab)

  • Machine Learning-Based Precision Medicine Approach Identifies Specific Responder Sub-Populations by Dynamic Clustering of PRO Data: Post Hoc Analysis of VARSITY Dataset
  • High-dimensional single-cell analysis identifies cellular signature associated with response to vedolizumab therapy in ulcerative colitis
  • Corticosteroid-Free Remission in Anti-TNF-Failed Crohn’s Disease Patients Treated With Vedolizumab as Second-Line Biologic Therapy: A Real-World Data Review
  • Vedolizumab Long-Term Treatment Persistence And Safety – Results From A Multinational Extended Access Programme Study

North American Society For Pediatric Gastroenterology, Hepatology & Nutrition (NASPGHAN), 2023

October 4 - 7, 2023

Annual forum for participants to learn about the latest advances in pediatric gastroenterology, hepatology, and nutrition, and to discuss current topics in clinical applications.

Gattex® (teduglutide)

  • Teduglutide Long-Term Safety and Effectiveness for a Pediatric Cohort Enrolled in an Observational, Prospective, Multi-Center Short Bowel Syndrome and Intestinal Failure Registry

European Society for Clinical Nutrition & Metabolism Congress (ESPEN), 2023

September 11 - 14, 2023

Annual global congress dedicated to clinical nutrition and metabolism, including basic and clinical research, education, and organization of consensus statements about clinical care.

American Neurogastro­enterology and Motility Society (ANMS), 2023

August 11 - 13, 2023

Annual meeting uncovering cutting-edge research ranging from basic neurogastroenterology, translational and clinical aspects of gastrointestinal motility, and functional disorders.

Motegrity® (prucalopride)

  • Prescription medication use in chronic idiopathic constipation in the USA from the healthcare professional perspective: a retrospective observational study
  • Management of chronic idiopathic constipation in US patients from the healthcare professional perspective: a retrospective observational study

Congress of the Intestinal Rehabilitation and Transplant Association (CIRTA), 2023

June 30 - July 3, 2023

Bi-annual congress promoting intestinal rehabilitation and transplantation as a safe, innovative science involving nutritional, medical, surgical and transplant therapies through education, policy development and research.

Gattex® (teduglutide)

  • Long-term safety analysis of teduglutide treatment in adult patients with short bowel syndrome and intestinal failure (SBS-IF): analysis from a prospective, multinational registry

Medication Resources

Entyvio®

(vedolizumab)

Videos

 

Watch videos focused on inflammatory bowel disease (IBD).

Focus on the Intestinal Immune System in IBD

Learn about how inflammation in the intestinal tract can lead to inflammatory bowel disease (IBD).