U.S. Medical
This site is intended for U.S. Healthcare Professionals.
To report an adverse event or product quality complaint, call 1-877-TAKEDA-7 (1-877-825-3327)
This site is intended for U.S. Healthcare Professionals.
To report an adverse event or product quality complaint, call 1-877-TAKEDA-7 (1-877-825-3327)
Not an actual patient.
Signs and symptoms of MMN include weakness in the hands, lower arms, and the lower limbs. Patients may experience cramping, involuntary contractions or twitching, and wasting of affected muscles.1 MMN is commonly misdiagnosed, which can lead to inappropriate treatment and progression of muscle weakness and/or disability.3,4,5,6,7
In the U.S., the prevalence of MMN is approximately 1 to 2 per 100,000, and the disease can mimic the early symptoms of amyotrophic lateral sclerosis (ALS, also known as Lou Gehrig’s disease), although it only has a third of the prevalence of ALS.3,8,9,10
First symptoms appear before the age of 50 in almost 80% of patients, with the mean age of onset at 40 years (range 20 to 70 years).3 Men are 2.7 times more likely to be affected by MMN than women.6
The diagnosis of MMN requires clinical weakness without objective sensory loss and without upper motor neuron signs:5,11
Normal results are required for sensory nerve conduction studies.5 Laboratory and electrodiagnostic tests may help confirm the diagnosis but may not be definitive:3
The exact mechanism of the disease is unknown.3 It is hypothesized that the slowed or faulty nerve conduction in MMN is due to demyelination of the myelin sheath or injury to the nerve itself by:3,13
CB is the characteristic finding in MMN and is believed to be the underlying electrophysiological cause of muscle weakness.4 However, axon loss rather than CB is the most important determinant of permanent weakness and disability.3
A differential diagnosis is necessary to differentiate MMN from diseases with similar symptoms, such as ALS and chronic inflammatory demyelinating polyneuropathy (CIDP).3,4,5 Even with an accurate diagnosis, treatment options for MMN are limited and are aimed at modulating the aberrant immune responses.4,11,14,15
The goals of treatment are to:
Reverse motor CB15
Limit damage to axons to prevent permanent nerve damage8,15
Limit damage to myelin sheath and mitigate impaired signal conduction in nerves3,11
Annual conference aiming to advance knowledge about the cause(s), pathogenesis, epidemiology, and clinical manifestations of muscle disease and related neuromuscular disorders and to develop and implement strategies to examine promising therapeutic interventions.
Annual meeting offering the most up-to-date education in pulmonary, sleep, and critical care medicine through simulation sessions and original research presentations with clinical relevance to practitioners.
Annual event with more than 2,500 members and non-members of the AMCP to engage on the latest innovations and most intentional networking in managed care pharmacy.
Annual meeting dedicated to the advancement of neuromuscular, musculoskeletal, and electrodiagnostic medicine.
Biennial meeting that covers the latest discoveries in basic and clinical science covering our expanding field, bringing together internationally renowned scientists and clinicians to present and discuss major developments in diagnosis, clinical management, genetics, and immunobiology of inborn errors of immunity.
National conference of IgNS bringing together professionals and practitioners from all disciplines and clinical specialties to advance Ig therapy practice, while providing networking and comprehensive education opportunities.
Global meeting featuring thought leaders from around the world focused on advancing patient care in allergy and immunology.
A national conference offering exclusive continuing education, legislative policy updates, hands-on workshops, lively exhibitors, and networking opportunities for the nurse practitioner community.
The largest peripheral nerve meeting globally, offering the latest international research across specialties in peripheral neuropathy.
The Association of Pulmonary Advanced Practice Providers (APAPP) is the first association to focus solely on advanced practice providers (APPs) working in the realm of pulmonary medicine. Join over 200 nurse practitioners and physician associates for in-depth reviews and discussions highlighting the latest developments and current concepts in pulmonary, critical care, and sleep medicine.
The flagship meeting of the EAACI and the world’s largest congress specializing in the field of allergy and clinical immunology.
Regional annual conference discussing the most current information from top experts in allergy, asthma, and immunology.
International conference showcasing the latest advances in pulmonary disease, critical illness, and sleep disorders for scientists and clinicians at all stages of their careers.
Leading global conference discussing how to establish, incentivize, and share value sustainable for health systems, patients, and technology developers.
Annual meeting with the goal of providing a stimulating forum with presentations and discussions on the latest advances in clinical immunology, including primary immunodeficiencies and immune dysregulatory diseases.
Large assembly of pharmacy and healthcare professionals dedicated to the issues of managed care pharmacy, offering immersive education sessions and keynote presentations.
Annual meeting in neurology promoting high quality patient-centric care in a variety of topics and specialties through various learning formats.
Annual conference ideal for infusion professionals or those seeking opportunities in the industry to come together and explore the latest trends in offering home-based services.
Every second year HAEi gathers HAE patients, caregivers, healthcare professionals, and industry representatives with a sole focus of sharing experience and knowledge on HAE topics.
Premier global educational event for allergists and immunologists, with thousands of attendees each year, discussing allergies, asthma, and immune deficiency disorders.
Annual scientific session uniting allergists, immunologists, nurses, and physician assistants aimed at maintaining the highest standard of practice in allergy care.
Global meeting featuring thought leaders from around the world focused on advancing patient care in allergy and immunology.
Annual event with more than 2,500 members and non-members of the AMCP to engage on the latest innovations and most intentional networking in managed care pharmacy.
The joint annual meeting of leading global societies dedicated to infectious disease research and advances.
Annual meeting offering the most up-to-date education in pulmonary, sleep, and critical care medicine through simulation sessions and original research presentations with clinical relevance to practitioners.
National conference of IgNS bringing together professionals and practitioners from all disciplines and clinical specialties to advance Ig therapy practice, while providing networking and comprehensive education opportunities.
Annual conference that invites state-of-the-art speakers from around the world to discuss basic science and clinical topics on allergy, asthma, and immunology.
Additional Resources
Find materials to help foster a deeper understanding of Multifocal Motor Neuropathy (MMN).
An overview of Multifocal Motor Neuropathy (MMN) clinical presentation and diagnostic considerations.
An overview of the task force guideline recommendations for diagnosing Multifocal Motor Neuropathy (MMN).
Medication Resources
[Immune Globulin Infusion(Human)]