Diagnosis
The diagnosis of EoE is dependent on clinical, endoscopic, and histologic findings. These findings include symptoms of esophageal dysfunction; endoscopic findings of rings, furrows, exudates, edema, stricture, narrowing, and crepe-paper mucosa; and eosinophilic infiltration, which is defined as ≥15 eosinophils per high power field (eos/hpf) on an esophageal biopsy, that is isolated to the esophagus.7 A diagnosis of EoE is not reliant on prior response to proton pump inhibitors (PPIs). EoE should be suspected if a patient presents with chronic signs and symptoms of esophageal dysfunction such as: dysphagia, food impaction, food refusal, failure to progress with food introduction, heartburn, regurgitation, vomiting, chest pain, odynophagia, abdominal pain and malnutrition.